The Dynamics of the Dengue Fever Virus and the Creation of its Vaccine

The Dynamics of the breakbone fever fever Virus and the Creation of its VaccineAbstractI investigated Dengue fever and the dynamics of creating a drug or vaccine totherapeutic it. aft(prenominal) acquiring a basic knowledge of the virus I come down into various topicsincluding variants on the virus such as Dengue dishonour Syndrome and DengueHemorrhagic Fever. Then I looked into the molecular structure of the distempers proteinsand how their shape relates to how it can be treated by drugs. professor Tantilloslectures nigh drug design, including pharmacokinetics, pharmacodynamics and ADMET(Absorption, Distri just nowion, Metabolism, Excretion, Toxicity) connected the concepts ofprotein molecular structure and rough-and-ready ways to treat indispositions. After researching thebasic history behind Dengue Fever, I came to the conclusion that Dengue Fever is anextremely prominent disease that has no cure and will be very difficult to cure in thefuture due to our lack of knowledg e about it.A nine-year-old boy in Campos dos Goytacazes, and urban region of Rio deJaneiro, was admitted into a hospital displaying a fever in excess of 103 degrees. He wastreated for his symptoms but there was no official diagnosis 6. A mean solar day subsequent he wasdischarged from the hospital, yet returned two days later with a worsening condition andelevated levels of his previous symptoms. On the fifth day he was diagnosed withDengue Fever Shock Syndrome (a derivative of Dengue Fever). eventually his conditionspiraled into anemia, heart murmurs, and gastritis. Dengue Fever (DF) is a knownFlavivirus 2, which falls into the same family of viruses such as Yellow fever,Hepatitis C, West Nile Virus and about fifty other viruses 4. DF is found in such placesas of import/Sou... ...222-2225 25 July 20085 Schlesinger, R. W. Dengue Viruses. Wien Springer-Verlag, 1977.6 SOUZA, Luiz Jos de, CARNEIRO, Helder Gonalves, SOUTO FILHO, Joo TadeuDamian et al. Hepatitis in Dengue Shock Sy ndrome. Braz J Infect Dis online. 2002, vol.6, no. 6 citado 2008-07-29, pp. 322-327. Disponvel em86702002000600010&lng=pt&nrm=iso. ISSN 1413-8670. doi 10.1590/S1413-867020020006000107 Tantillo. (Lectures 23 July 2008 and 25 July 2008)8 Whitehead, Steven S., Joseph E. Blaney, Anna P. Durbin, and Brian R. Murphy.Prospects for a Dengue Virus Vaccine. Nature Reviews 5 (2007) 518-28. 25 July 20089 Xinhua. Thailand to test Mahidol-developed dengue vaccine prototype. PeoplesDaily Online 05 Sept. 2005.